Congestive heart failure
|
0.800 |
Biomarker
|
disease |
RGD |
Protective effect of oxymatrine on chronic rat heart failure.
|
21691940 |
2011 |
Congestive heart failure
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
During end-stage human heart failure, we have demonstrated that type 1 IP3R (IP3R1) mRNA and protein levels are up-regulated, in contrast to other cardiac calcium regulatory proteins, such as the type 2 ryanodine receptor (RYR2) and type IIa sarcoplasmic reticulum calcium adenosine triphosphatase (SERCA2), which are down-regulated.
|
9476544 |
1997 |
Congestive heart failure
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Therapeutic upregulation of SERCA2 expression using replication deficient adenoviral expression vectors, pharmacological interventions using thyroid hormone analogues, beta-adrenergic receptor antagonists, and novel metabolically active compounds are currently under investigation for the treatment of uncompensated cardiac hypertrophy and heart failure.
|
16902596 |
2006 |
Congestive heart failure
|
0.800 |
Biomarker
|
disease |
BEFREE |
Our findings show a crucial role of LRP1/Pyk2/HIF-1α in hypoxia-induced cardiomyocyte SERCA2 downregulation, a pathophysiological process closely associated with heart failure.
|
25968337 |
2015 |
Congestive heart failure
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Our results highlight the interaction of Yulink with PPARγ in regulating Serca2 expression and suggest a mechanistic role of the Yulink in the development of human heart failure and SCD.-Tsai, C.-T., Kuo, M.-W., Lin, J.-L., Yu, A. L., Yu, J.
|
29401584 |
2018 |
Congestive heart failure
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Phospholamban (PLB) inhibits SERCA2 activity and is therefore a potential target to improve the cardiac performance in heart failure.
|
10468529 |
1999 |
Congestive heart failure
|
0.800 |
Biomarker
|
disease |
BEFREE |
In this review we describe the drugs adopted in clinical practice that activate SERCA2a/b function as well as new promising therapeutic tools using SERCA2 viral gene delivery to improve cardiac function and treat heart failure.
|
24361307 |
2014 |
Congestive heart failure
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
A reduced activity and expression of SERCA2 protein have been described in heart failure and diabetic cardiomyopathy, resulting in an altered Ca(2+) handling and cardiac contractility.
|
25270119 |
2014 |
Congestive heart failure
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
This finding led us to explore the expression of the presently known cardiac Ca2+-ATPase isoforms in heart failure.
|
16402920 |
2006 |
Congestive heart failure
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The observation that ATP2A2 rs1860561 gene variant associated with lower risk of life-threatening arrhythmia in HF patients suggests that selected calcium gene variants may modify the risk of SD even within the complex and polygenic pathological condition of HF.
|
24048583 |
2013 |
Congestive heart failure
|
0.800 |
Biomarker
|
disease |
BEFREE |
Strikingly, these mice show a rapid decrease in cardiac contractility and a rapid loss of SERCA2 protein, which is also seen in heart failure.
|
30575439 |
2019 |
Congestive heart failure
|
0.800 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Congestive heart failure
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
These data also show that the altered SR function in human heart failure cannot be explained by altered protein levels of PLB and SERCA2.
|
8689655 |
1996 |
Congestive heart failure
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
These data reveal myofibrillar Ca(2+)-sensitivity to be an important determinant of the cardiac effects of SERCA2 haploinsufficiency and raise the possibility that Darier disease patients are more susceptible to heart failure under certain conditions.
|
26064889 |
2015 |
Congestive heart failure
|
0.800 |
Biomarker
|
disease |
CTD_human |
Differential contractile impairment of fast- and slow-twitch skeletal muscles in a rat model of doxorubicin-induced congestive heart failure.
|
19776660 |
2009 |